Mucormycosis is a rare, rapidly progressive and often fatal opportunistic fungal infection, which occurs most commonly in patients with uncontrolled diabetes. We reported a case of rhinoorbital mucormycosis confirmed by nasal mucosal biopsy,
which
showed characteristic fungal hyphae and vascular invasion.
The patient was a 41-year-old woman, who had diabetes mellitus for 5 years, presented with a 20ady history of redness and swelling in the left eyelid and maxillary area. On the admission, blood glucose was 412mg/dl.
Brain CT revealed pansinusitis, air-fluid level in the maxillary sinus, preorbital swelling and soft tissue density in the nasal cavity. But there was no demonstrable bony destruction.
After aggressive surgical resection, systemic intravenous amphotericin B(1.0 mg/kg/day) was given for 7 weeks to a total dose of 2.0g. On the 72th hospital day, she developed sudden, unexpected alteration of consciousness followed by coma. Two
days
later, the patient died and an autopsy was not performed.
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